Endocrine Abstracts

Pathogenesis of Non-alcoholic fatty liver disease in 90% combined with diabetes mellitus (DM) of the second type. Factors cutting: abdominal obesity, excessive content of free fatty acids. Development of insulin resistance through protein kinase. Violation of the transmission of insulin signal leads to damage to the endothelium. Glycation of nitric oxide synthase leads to the development of diabetic complications and violates the sensitivity of the insulin receptors.<p cla...

Obesity affects on the composition of bile: the lithogenicity of bile increases, biliary sludge and cholelithiasis are developing. Under the influence of the active form of oxygen, abnormal forms of bile acids are formed, which negatively affects the development and progression of the pathological process. With the development of inflammation in the liver and pancreas, disturbances in the membrane proteins of glucose transporters occur, the activity of nuclear receptors for th...

Retinol binding protein (RBP) is an adipokine, related to insulin resistance (IR). Excess free fat acid reduces the binding of insulin by hepatocyte receptors and leads to hyperinsulinemia. RBP transport protein synthesized in hepatocytes and adipocytes. The level of RBP increases in patients with obesity, diabetes and non-alcoholic fatty liver disease (NAFLD). It is positively correlated with the degree of severity of the inflammatory process and fibrosis. The RBP regulates t...

Purpose: To study the state of the microvasculature and tissue metabolism (according to the dynamics of the FAD and NADH coenzymes) using laser Doppler fluometry (LDF) and laser fluorescence spectroscopy (LFS) in patients with diabetes mellitus.Materials and methods: To implement the combined use of LDF and LFS methods, the Laser Diagnostic Device LAZMA ST was used (registration certificate of Roszdravnadzor No. RZN 2017/5844 of June 08, 2017).<p cla...

Methylglyoxal (MG) damages arginine protein residues, inhibits enzymes, disrupts insulin signal transmission, and plays a key role in the development of insulin resistance and hyperglycemia. High glucose levels cause an increase in glycation and methylglyoxal formation. Glycation is the main cause of protein damage, leading to the production of free radicals and causing inflammation.The purpose of the study: To Identify the relationship of methylglyoxal ...

Glycation is due to the ability of glucose to form irreversible chemical compounds with amino groups of lysine and arginine – methylglyoxal (MG).Material and Methods: 98 patients with NAFLD and 52 patients with NAFLD were examined. Diabetes 2-type, and 22 healthy volunteers. Age 57.3 ± 5.2 years. BMI 34.85 ± 1.79. The diagnosis was established on the basis of laboratory data and examination results. The level of LPO was determinedby the c...

Bile acids (BA) regulate glucose and lipid metabolism, provide bile flow, increase lipase activity by 10–15 times. With the development of inflammation, violations occur in the membrane proteins of glucose transporters.AimDetermine the total pool of bile acids in NAFLD with diabetes mellitus (DM) and impaired glucose tolerance (IGT). Determine the content of inflammation markers lipoprotein-associated phospholipase (Lp-PLA2), ...

Retinol binding protein (RBP) is an adipokine, related to insulin resistance (IR). Excess free fat acid reduces the binding of insulin by hepatocyte receptors and leads to hyperinsulinemia. RBP transport protein synthesized in hepatocytes and adipocytes. The level of RBP increases in patients with obesity, diabetes andnon-alcoholic fatty liver disease (NAFLD). It is positively correlated with the degree of severity of the inflammatory process and fibrosis. The RBP regulates th...

AimTo assess the effect of Zakofalk in complex therapy in patients with type 2 diabetes and obesity.Materials and methodsWe examined 68 patients with type 2 diabetes and 28 with obesity (body mass index over 30 kg/m2). The control group consisted of 20 people. The groups were comparable in terms of age, sex, and antihyperglycemic therapy. In addition to a thorough clinical examination of all study ...

AimAnalyze a number of foreign sources to assess the risks of developing post-transplant diabetes mellitus (PTSD).Materials and methodsIn total, we analyzed more than 70 sources from Western Europe, East Asia and South Africa. Pancreatic β-cell dysfunction, impaired insulin secretion associated with the use of calcineurin inhibitors and inhibitors of the mammalian target of rapamycin complex 1 (mTORC1), ...